Honeybees may hold the secret to stem cell youth

Honeybees may hold the secret to stem cell youth

From Medical News Today https://www.medicalnewstoday.com/articles/323904.php


Royal jelly is a gelatinous substance that honeybees produce to feed their young. This intriguing food also holds the mysterious power of helping some honeybee larvae grow into new queen bees. Some people believe that royal jelly can unlock the fountain of youth. Is there any truth in that?

In the complex hierarchy of the beehive, the queen bee is the sacred matriarch who keeps the colony alive and organized.

The queen bee lays the eggs from which the larvae will hatch. These larvae later become either the new workers, which are the female bees who do all the work around the hive, or the drones, the male bees whose job it is to mate with the queen.

When a queen bee dies, the colony has to ensure that a new one takes her place.

To produce a new queen bee, worker bees select the most suitable larvae and feed them royal jelly. This will allow one of them to develop into the healthy, strong, and extremely fertile adult female who then becomes the new queen bee.

Royal jelly comprises water, proteins, and sugars, but how exactly it stimulates some larvae to grow into queens rather than worker bees has remained unclear.

Still, due to its seemingly “magical” properties, many people hail this substance as a miraculous ingredient that can boost health and help maintain youth.

In a new study from the Stanford University School of Medicine in California, a team of researchers has decided to investigate how and why royal jelly might be beneficial. They have looked at its effect on one of the most promising targets of clinical research, namely mammalian stem cells. These undifferentiated cells are capable of turning into any specialized cells, serving any function.

“In folklore, royal jelly is kind of like a super-medicine, particularly in Asia and Europe, but the DNA sequence of royalactin, the active component in the jelly, is unique to honeybees. Now, we’ve identified a structurally similar mammalian protein that can maintain stem cell pluripotency,” explains senior author Dr. Kevin Wang.

The researchers tell the story of their current findings in the journal Nature Communications.